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Dieter Willbold Selected Research

D3 peptide

11/2021All-d-Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors.
9/2017Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs.
11/2016Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide.
1/2014The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity.
9/2010Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.

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Dieter Willbold Research Topics

Disease

69Alzheimer Disease (Alzheimer's Disease)
01/2022 - 08/2003
15Amyloid Plaque
01/2022 - 08/2003
13Neurodegenerative Diseases (Neurodegenerative Disease)
06/2022 - 04/2008
9Parkinson Disease (Parkinson's Disease)
01/2022 - 04/2008
5Infections
01/2022 - 02/2010
5Neoplasms (Cancer)
01/2022 - 07/2012
5Proteostasis Deficiencies
12/2021 - 04/2011
5Prion Diseases (Transmissible Spongiform Encephalopathies)
01/2013 - 04/2008
4Inflammation (Inflammations)
10/2020 - 02/2009
3COVID-19
02/2022 - 01/2021
3Schizophrenia (Dementia Praecox)
12/2021 - 01/2017
3Mental Disorders (Mental Disorder)
12/2021 - 01/2017
3Glioblastoma (Glioblastoma Multiforme)
11/2021 - 11/2016
3Amyloidosis
06/2021 - 01/2019
3Glioma (Gliomas)
01/2020 - 01/2015
3Type 2 Diabetes Mellitus (MODY)
01/2020 - 12/2014
3Scrapie
01/2012 - 08/2007
2Cognitive Dysfunction
06/2021 - 01/2016
2Mitochondrial Diseases (Mitochondrial Disease)
08/2020 - 10/2017
2Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
10/2018 - 01/2016
2Dementia (Dementias)
01/2018 - 07/2009
2Synucleinopathies
03/2017 - 04/2014
2Disease Progression
01/2012 - 02/2009
1Rhabdoid Tumor (Rhabdoid Tumors)
01/2022
1X-Linked Bulbo-Spinal Atrophy
01/2022
1Medulloblastoma
01/2022
1Classical Lissencephalies and Subcortical Band Heterotopias
12/2021
1Starvation
11/2021
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2021
1Coinfection
01/2021
1Atherosclerosis
10/2020
1Thrombosis (Thrombus)
10/2020
1Memory Disorders (Memory Loss)
11/2017
1Genetic Translocation (Chromosomal Translocation)
01/2017
1Brain Neoplasms (Brain Tumor)
11/2016
1Hemorrhage
01/2016
1Thrombasthenia (Glanzmann Thrombasthenia)
01/2016

Drug/Important Bio-Agent (IBA)

58Amyloid (Amyloid Fibrils)IBA
01/2022 - 08/2003
35Peptides (Polypeptides)IBA
02/2022 - 08/2003
30Proteins (Proteins, Gene)FDA Link
06/2022 - 08/2008
13Amyloid beta-PeptidesIBA
01/2022 - 09/2007
8Pharmaceutical PreparationsIBA
01/2022 - 11/2016
8Amino AcidsFDA Link
01/2020 - 08/2003
7SynucleinsIBA
01/2019 - 04/2014
5D3 peptideIBA
11/2021 - 09/2010
5Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA
06/2021 - 07/2009
5Biomarkers (Surrogate Marker)IBA
08/2020 - 01/2012
5Protein Isoforms (Isoforms)IBA
04/2017 - 09/2008
5Prion ProteinsIBA
01/2014 - 09/2008
4Islet Amyloid PolypeptideIBA
01/2020 - 12/2014
4LigandsIBA
01/2012 - 08/2003
2alpha-SynucleinIBA
06/2022 - 01/2022
2Dyneins (Dynein)IBA
01/2022 - 12/2021
2Glutamine (L-Glutamine)FDA Link
11/2021 - 01/2020
2SolutionsIBA
08/2020 - 08/2007
2PrionsIBA
06/2019 - 01/2019
2Intrinsically Disordered ProteinsIBA
06/2019 - 07/2015
2tau Proteins (tau Protein)IBA
01/2019 - 01/2016
2Choline (Choline Chloride)IBA
11/2016 - 01/2015
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
06/2022
1Androgen Receptors (Androgen Receptor)IBA
01/2022
1polyglutamineIBA
01/2022
1Long Noncoding RNAIBA
01/2022
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021
1AntiportersIBA
11/2021
1Glutamic Acid (Glutamate)FDA Link
11/2021
1Protons (Proton)IBA
11/2021
1Cystine (L-Cystine)IBA
11/2021
1Zinc Finger E-box-Binding Homeobox 1IBA
11/2021
1Drug CombinationsIBA
10/2021
14- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA
01/2021
1Peptide Hydrolases (Proteases)FDA Link
01/2021
1Superoxide Dismutase-1IBA
01/2021
1Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA
10/2020
1Adenosine Triphosphate (ATP)IBA
08/2020
1Biological ProductsIBA
01/2020
1LipidsIBA
01/2020
1NucleotidesIBA
01/2020
1EnzymesIBA
01/2020
1GlutaminaseIBA
01/2020
1TubulinIBA
06/2019
1Carrier Proteins (Binding Protein)IBA
06/2019
1Inosine Diphosphate (IDP)IBA
06/2019
1dityrosineIBA
10/2017
1Phosphorylcholine (Phosphocholine)IBA
11/2016
1Arginine (L-Arginine)FDA Link
11/2016
1Human Immunodeficiency Virus tat Gene ProductsIBA
11/2016
1Trans-Activators (Trans-Acting Factor)IBA
11/2016
1Silicon Dioxide (Silica)FDA LinkGeneric
01/2016
1IntegrinsIBA
01/2016
1ClusterinIBA
01/2016
1Amyloidogenic ProteinsIBA
02/2015
1Inositol (Myoinositol)IBA
01/2015
1CreatineIBA
01/2015
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2015

Therapy/Procedure

11Therapeutics
02/2022 - 08/2003
2Oral Administration
01/2019 - 09/2017
1Combined Modality Therapy
11/2016
1Drug Therapy (Chemotherapy)
11/2016
1Transplantation
01/2016